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Science-based risk governance of nanotechnology (RiskGone)

Project details

Website: https://riskgone.wp.nilu.no/

Status: Ongoing

Project period: 2019–2023

Principal: EU (814425)

Coordinating institution: NILU

Engineered nanomaterials (ENMs) are covered by REACH/CLP regulations; the general opinion is that the risk assessment (RA) approach routinely used for conventional chemicals is also applicable to ENMs. However, as acknowledged by OECD and ECHA, the OECD and ISO Test Guidelines (TGs) and Standard Operating Procedures (SOPs) need to be verified and adapted to be applicable to ENMs.

Engineered nanomaterials (ENMs) provide the opportunity for breakthroughs in health care, chemical and technology industry. However, ENMs’ unpredictable impact on human health generates increasing concern from the public, academia, and governments worldwide.

ENMs are subject to REACH/CLP regulations. The test procedures need to be verified and adapted for specific use for ENMs (OECD and ISO Test Guidelines (TGs) and Standard Operating Procedures (SOPs)). The national legal frameworks and the international regulations need to be harmonized. RiskGone, a newly financed H2020 project (H2020-NMBP-13-2018 RIA), aims at providing solid procedures for science-based inter-disciplinary risk governance, based on a clear understanding of risks, risk management practices and the societal risk perception by all stakeholders.

This workshop will bring together national and international experts in different aspects of the risk governance of nanotechnology, promoting the establishment of contacts, discussions and collaborations between researchers, society stakeholders and public administration. The workshop will also promote a technical discussion between the participants of RiskGONE project with other nanosafety experts and community.

NILU is RiskGONE project coordinator and acts as a host of the workshop. The workshop participants will come from highly experienced and internationally recognized institutes with long-standing expertise in multidisciplinary areas of nanosafety such as characterisation, human-related nano-toxicology, environmental hazard, safety governance, social science, ethics, and communication.

The workshop will feature oral presentations and discussion sessions in order to provide attendees with various channels to exchange and acquire information about the latest developments and future trends. It will provide a platform for strengthening existing national and international collaborations, as well as establishing new ones.

Updated: 17.09.2021

Science-based risk governance of nanotechnology has 21 publications at NILU:

European Registry of Materials: global, unique identifiers for (undisclosed) nanomaterials

van Rijn, Jeaphianne; Afantitis, Antreas; Culha, Mustafa; Dusinska, Maria; Exner, Thomas E.; Jeliazkova, Nina; Longhin, Eleonora Marta; Lynch, Iseult; Melagraki, Georgia; Nymark, Penny; Papadiamantis, Anastasios; Winkler, David A.; Yilmaz, Hulya; Willighagen, Egon

2022

Hazard identification of nanomaterials: In silico unraveling of descriptors for cytotoxicity and genotoxicity

El Yamani, Naouale; Mariussen, Espen; Gromelski, Maciej; Wyrzykowska, Ewelina; Grabarek, Dawid; Puzyn, Tomasz; Tanasescu, Speranta; Dusinska, Maria; Rundén-Pran, Elise

2022

Do cytotoxicity and cell death cause false positive results in the in vitro comet assay?

Azqueta, Amaya ; Stopper, Helga; Zegura, Bojana; Dusinska, Maria; Møller, Peter

2022

Do Carbon Nanotubes and Asbestos Fibers Exhibit Common Toxicity Mechanisms?

Gupta, Suchi Smita; Singh, Krishna P.; Gupta, Shailendra; Dusinska, Maria; Rahman, Qamar

2022

Standardisation of mutagenicity testing approaches, tailored to the evaluation of engineered nanomaterials

Burgum, Michael J.; El Yamani, Naouale; Sosnowska, Anita; Stolinski, Filip; Longhin, Eleonora Marta; Mariussen, Espen; Rundén-Pran, Elise; Jenkins, Gareth; Clift, Martin J. D.; Puzyn, Tomasz; Dusinska, Maria; Doak, Shareen H.

2021

IDENTIFYING THE RELEVANCE OF EXISITING ADVERSE OUTCOME PATHWAYS FOR NANOMATERIALS

Murugadoss, Sivakumar; Vrček, Ivana Vinković; Cimpan, Mihaela-Roxana; Pem, Barbara; Martens, Marvin; Willihagen, Egon; Sosnowska, Anita; Puzyn, Tomasz; Dusinska, Maria; Fessard, Valérie; Hoet, Peter

2021

A strategy towards the generation of testable adverse outcome pathways for nanomaterials

Murugadoss, Sivakumar; Vrcek, Ivana Vinkovic; Pem, Barbara; Jagiello, Karolina; Judzinska, Beata; Sosnowska, Anita; Martens, Marvin; Willighagen, Egon L.; Puzyn, Tomasz; Dusinska, Maria; Cimpan, Mihaela-Roxana; Fessard, Valérie; Hoet, Peter H.

2021

Towards FAIR nanosafety data

Jeliazkova, Nina; Apostolova, Margarita D.; Andreoli, Cristina; Barone, Flavia; Barrick, Andrew; Battistelli, Chiara L.; Bossa, Cecilia; Botea-Petcu, Alina; Chatel, Amelie; De Angelis, Isabella; Dusinska, Maria; El Yamani, Naouale; Gheorghe, Daniela; Giusti, Anna; Gómez-Fernández, Paloma; Grafström, Roland; Gromelski, Maciej; Jacobsen, Nicklas Raun; Jeliazkov, Vedrin; Jensen, Keld Alstrup; Kochev, Nikolay; Kohonen, Pekka; Manier, Nicolas; Mariussen, Espen; Mech, Agnieszka; Navas, José María; Paskaleva, Vesselina; Precupas, Aurica; Puzyn, Tomasz; Rasmussen, Kirsten; Ritchie, Peter; Llopis, Isabel Rodriguez; Rundén-Pran, Elise; Sandu, Romica; Shandilya, Neeraj; Tanasescu, Sperenta; Haase, Andrea; Nymark, Penny

2021

Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance

Lynch, Iseult; Afantitis, Antreas; Greco, Dario; Dusinska, Maria; Banares, Miguel A.; Melagraki, Georgia

2021

Reflecting on Ethics of Nanosafety

Malsch, Ineke; Panagiotis, Isigonis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Lynch, Iseult; Cimpan, Mihaela-Roxana; Dusinska, Maria

2020

Screening Nano-Ethical Issues

Malsch, Ineke; Isigonis, Panagiotis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Lynch, Iseult; Cimpan, Mihaela-Roxana; Dusinska, Maria

2020

Reflecting on Ethical, Legal and Societal Aspects of Nanosafety

Malsch, Ineke; Panagiotis, Isigonis; Bouman, Evert; Afantitis, Antreas; Melagraki, Georgia; Lynch, Iseult; Cimpan, Mihaela-Roxana; Dusinska, Maria

2020

Generation of testable adverse outcome pathways (AOPs) for nanomaterial human hazard assessment

Murugadoss, Sivakumar; Vincovik Vrcek, Ivana; Cimpan, Mihaela-Roxana; Martens, Marvin; Gromelski, Maciej; Puzyn, Tomasz; Fessard, Valérie; Lynch, Iseult; Dusinska, Maria; Hoet, Peter

2020

Development of an Adverse Outcome Pathway for Chronic and Multi-Generational Impacts of Nanomaterials in the Environmental Indicator Species Daphnia Magna

Lynch, Iseult; Reilly, Katie; Cimpan, Mihaela Roxana; Drønen, Anne-Marthe; Rios-Mondragon, Ivan; Cambier, Sébastien; Gutleb, Arno; Serchi, Tommaso; Dusinska, Maria; Rundén-Pran, Elise; Mariussen, Espen; Longhin, Eleonora Marta; Murugadoss, Sivakumar; Hoet, Peter; Willihagen, Egon; Martens, Marvin; Afantitis, Antreas; Melargakis, Georgia; Vincovik Vrcek, Ivana

2020

Genotoxicity of nanomaterials: Advanced in vitro models and high throughput methods for human hazard assessment—a review

Kohl, Yvonne; Rundén-Pran, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora Marte; Dusinska, Maria

2020

Risk governance of emerging technologies demonstrated in terms of its applicability to nanomaterials

Isigonis, Panagiotis; Afantitis, Antreas; Antunes, Dalila; Bartonova, Alena; Beitollahi, Ali; Bohmer, Nils; Bouman, Evert; Chaudhry, Qasim; Cimpan, Mihaela Roxana; Cimpan, Emil; Doak, Shareen; Dupin, Damien; Fredrigo, Doreen; Fessard, Valérie; Gromelski, Maciej; Gutleb, Arno C.; Halappanavar, Sabina; Hoet, Peter; Jeliazkova, Nina; Jomini, Stephane; Lindner, Sabine; Linkov, Igor; Longhin, Eleonora Marte; Lynch, Iseult; Malsch, Ineke; Marcomini, Antonio; Mariussen, Espen; de la Fuente, Jesus M.; Melagraki, Georgia; Murphy, Finbarr; Neaves, Michael; Packroff, Rolf; Pfuhler, Stefan; Puzyn, Tomasz; Rahman, Qamar; Rundén-Pran, Elise; Semenzin, Elena; Serchi, Tommaso; Steinbach, Christoph; Trump, Benjamin; Vrcek, Ivana Vinkovic; Warheit, David; Wiesner, Mark R,; Willighagen, Egon; Dusinska, Maria

2020

Embedding Ethical Impact Assessment in Nanosafety Decision Support

Malsch, Ineke; Isigonis, Panagiotis; Dusinska, Maria; Bouman, Evert

2020

Thermodynamic parameters at bio-nano interface and nanomaterial toxicity: A case study on BSA interaction with ZnO, SiO2 and TiO2

Precupas, Aurica; Gheorghe, Daniela; Botea-Petcu, Alina; Leonties, Anca Ruxandra; Sandu, Romica; Popa, Vlad Tudor; Mariussen, Espen; El Yamani, Naouale; Rundén-Pran, Elise; Dumit, Veronica; Xue, Ying; Cimpan, Mihaela Roxana; Dusinska, Maria; Haase, Andrea; Tanasescu, Speranta

2020

Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Rundén-Pran, Elise

2020

Effects of titanium dioxide nanoparticles on the Hprt gene mutations in V79 hamster cells

Kazimirova, Alena; El Yamani, Naouale; Rubio, Laura; Garcia-Rodriguez, Alba; Barancokova, Magdalena; Marcos, Ricard; Dusinska, Maria

2020