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Elise Rundén-Pran

Senior Scientist / Head of Section for the Health Effects Laboratory

+47 63 89 82 37

Environmental Chemistry Department
Kjeller

erp@nilu.no


Cristin  

Elise Rundén Pran

Dr. Rundén-Pran is senior scientist and section leader for Health Effects Laboratory and ERT registered toxicologist.

She has extensive experience in toxicology, nanotoxicology, nanosafety, cell cultures, 3D-cellular models, nanogenotoxicology, DNA damage, intracellular cell death signaling, microscopy (confocal, TEM), immunohistochemistry, tissue slice cultures and neurodegeneration.

She was part of the Centre for Excellence in Molecular Neurobiology and DNA repair (UiO) for several years (PhD and Postdoc). She is experienced with human risk assessment and regulatory toxicology, partner leader in EURONANOMED II projects GEMNS and INNOCENT, and NILU project leader for several projects funded by EU and NFR. She has extensive experience in GLP, and is appointed member of the national committee for approval of European registered toxicologists (ERT), The Norwegian Scientific Committee for Food and Environment, and member of the national expert group for toxicology.

The Health Effects Laboratory is certified for Good Laboratory Practice (GLP) for in vitro human toxicity studies. The laboratory is among the leading laboratories in Europe in nanotoxicology and nanosafety, and main areas of interest are genotoxicity, carcinogenicity in vitro, epigenetics, advanced in vitro models, regulatory aspects of nanosafety,  high-throughput approach to toxicity testing, intelligent testing strategy and adverse outcome pathways.

Elise Rundén-Pran has 79 publications at NILU

Conference lecture and academic presentation

Financial management

Longhin, Eleonora; Runden, Elise
2021

Conference lecture and academic presentation

Nanosafety: challenges and opportunities

Runden, Elise
2021

Journal publication

An Advanced In vitro Respiratory Model for Genotoxicity Testing at the Air-Liquid Interface

Runden, Elise; Mariussen, Espen; Elje, Elisabeth; Chary, A.; Longhin, Eleonora; El Yamani, Naouale; Dusinska, Maria; Gutleb, A.; Serchi, T.
2021

Journal publication

In silico unravelling of descriptors for cytotoxicity and genotoxicity for hazard identification of nanomaterials

El Yamani, Naouale; Gromelski, Maciej; Mariussen, Espen; Wyrzykowska, E.; Grabarek, D.; Puzyn, Tomasz; Dusinska, Maria; Runden, Elise
2021

Journal publication

Micronucleus assay applied to advanced in vitro lung models at ALI for nanotoxicity assessment

Elje, Elisabeth; Mariussen, Espen; Dusinska, Maria; Runden, Elise
2021

Journal publication

Standardisation of mutagenicity testing approaches, tailored to the evaluation of engineered nanomaterials

Burgum, Michael J.; El Yamani, Naouale; Sosnowska, Anita; Stolinski, Filip; Longhin, Eleonora; Mariussen, Espen; Runden, Elise; Jenkins, Gareth; Clift, Martin J. D.; Puzyn, Tomasz; Dusinska, Maria; Doak, Shareen H.
2021

Journal publication

Towards FAIR nanosafety data

Jeliazkova, Nina; Apostolova, Margarita; Andreoli, Cristina; Barone, Flavia; Barrick, Andrew; Battistelli, Chiara L.; Bossa, Cecilia; Botea-Petcu, Alina; Chatel, Amelie; De Angelis, Isabella; Dusinska, Maria; El Yamani, Naouale; Gheorghe, Daniela; Giusti, Anna; Gómez-Fernández, Paloma; Grafström, Roland; Gromelski, Maciej; Jacobsen, Nicklas Raun; Jeliazkov, Vedrin; Jensen, Keld Alstrup; Kochev, Nikolay; Kohonen, Pekka; Manier, Nicolas; Mariussen, Espen; Mech, Agnieszka; Navas, José María; Paskaleva, Vesselina; Precupas, Aurica; Puzyn, Tomasz; Rasmussen, Kirsten; Ritchie, Peter; Llopis, Isabel Rodriguez; Runden, Elise; Sandu, Romica; Shandilya, Neeraj; Tanasescu, Sperenta; Haase, Andrea; Nymark, Penny
2021

Journal publication

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening

Kohl, Yvonne; Biehl, Margit; Spring, Sarah; Hesler, Michelle; Ogourtsov, Vladimir; Todorovic, Miomir; Owen, Joshua; Elje, Elisabeth; Kopecka, Kristina; Moriones, Oscar H.; Bastus, Neus G.; Simon, Peter; Dubaj, Tibor; Runden, Elise; Puntes, Victor; William, Nicola; von Briesen, Hagen; Wagner, Sylvia; Kapur, Nikil; Mariussen, Espen; Nelson, Andrew; Gabelova, A; Dusinska, Maria; Velten, Thomas; knoll, Thorsten
2021

Journal publication

A scoping review of systematic reviews on environmental effects of sunscreen ingredients. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids, Materials in Contact with Food, and Cosmetics of the Norwegian Scientific Committee for Food and Environment

Svendsen, Camilla; Asmyhr, Maria Gulbrandsen; Denison, Eva Marie-Louise; Devold, Tove Gulbrandsen; Mathisen, Gro Haarklou; Rohloff, Jens; Starrfelt, Jostein; Bruzell, Ellen; Carlsen, Monica Hauger; Granum, Berit; Runden, Elise; Rasinger, Josef Daniel; Husøy, Trine
2020

Conference lecture and academic presentation

Development of an Adverse Outcome Pathway for Chronic and Multi-Generational Impacts of Nanomaterials in the Environmental Indicator Species Daphnia Magna

Lynch, Iseult; Reilly, Katie; Cimpan, Mihaela Roxana; Drønen, Anne-Marthe; Rios-Mondragon, Ivan; Cambier, Sébastien; Gutleb, Arno; Serchi, Tommaso; Dusinska, Maria; Runden, Elise; Mariussen, Espen; Longhin, Eleonora; Murugadoss, Sivakumar; Hoet, Peter; Willihagen, Egon; Martens, Marvin; Afantitis, Antreas; Melargakis, Georgia; Vincovik Vrcek, Ivana
2020

Journal publication

Safe(r) by design implementation in the nanotechnology industry

Jiménes, Araceli Sánchez; Puelles, Raquel; Pérez-Fernández, Marta; Gómez-Fernández, Paloma; Barruetabena, Leire; Jacobsen, Nicklas Raun; Suarez-Merino, Blanca; Micheletti, Christian; Manier, Nicolas; Trouiller, Benedicte; Navas, José Maria; Kalman, Judit; Salieri, Beatrice; Hischier, Roland; Handzhiyski, Yordan; Apostolova, Margarita; Hadrup, Niels; Bouillard, Jaques; Oudart, Yohan; Merino, Cesar; Garcia, Erika; Liguori, Biase; Sabella, Stefania; Rose, Jerome; Maison, Armand; Galea, Karen S.; Kelly, Sean; Stepankova, Sandra; Mouneyrac, Catherine; Barrick, Andrew; Chatel, Amelie; Dusinska, Maria; Runden, Elise; Mariussen, Espen; Bressot, Christophe; Aguerre-Chariol, Olivier; Shandilya, Neeraj; Goede, Henk; Gomez-Cordon, Julio; Simar, Sophie; Nesslany, Fabrice; Jensen, Keld Alstrup; Van Tongeren, Martie; Llopis, Isabel Rodriguez
2020

Journal publication

Genotoxicity of nanomaterials: Advanced in vitro models and high throughput methods for human hazard assessment—a review

Kohl, Yvonne; Runden, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora; Dusinska, Maria
2020

Journal publication

Risk governance of emerging technologies demonstrated in terms of its applicability to nanomaterials

Isigonis, Panagiotis; Afantitis, Antreas; Antunes, Dalila; Bartonova, Alena; Beitollahi, Ali; Bohmer, Nils; Bouman, Evert; Chaudhry, Qasim; Cimpan, Mihaela Roxana; Cimpan, Emil; Doak, Shareen H.; Dupin, Damien; Fredrigo, Doreen; Fessard, Valérie; Gromelski, Maciej; Gutleb, Arno C.; Halappanavar, Sabina; Hoet, Peter; Jeliazkova, Nina; Jomini, Stephane; Lindner, Sabine; Linkov, Igor; Longhin, Eleonora; Lynch, Iseult; Malsch, Ineke; Marcomini, Antonio; Mariussen, Espen; de la Fuente, Jesus M.; Melagraki, Georgia; Murphy, Finbarr; Neaves, Michael; Packroff, Rolf; Pfuhler, Stefan; Puzyn, Tomasz; Rahman, Qamar; Runden, Elise; Semenzin, Elena; Serchi, Tommaso; Steinbach, Christoph; Trump, Benjamin; Vrcek, Ivana Vinkovic; Warheit, David; Wiesner, Mark; Willighagen, Egon; Dusinska, Maria
2020

Journal publication

Thermodynamic parameters at bio-nano interface and nanomaterial toxicity: A case study on BSA interaction with ZnO, SiO2 and TiO2

Precupas, Aurica; Gheorghe, Daniela; Botea-Petcu, Alina; Leonties, Anca Ruxandra; Sandu, Romica; Popa, Vlad T.; Mariussen, Espen; El Yamani, Naouale; Runden, Elise; Dumit, Veronica; Xue, Ying; Cimpan, Mihaela Roxana; Dusinska, Maria; Haase, Andrea; Tanasescu, Speranta
2020

Journal publication

NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment

Afantitis, Antreas; Melagraki, Georgia; Isigonis, Panagiotis; Tsoumanis, Andreas; Varsou, Dimitra Danai; Valsami-Jones, Eugenia; Papadiamantis, Anastasios; Ellis, Laura-Jayne; Sarimveis, Haralambos; Doganis, Philip; Karatzas, Pantelis; Tsiros, Periklis; Liampa, Irene; Lobaskin, Vladimir; Greco, Dario; Serra, Angela; Kinaret, Pia Anneli Sofia; Saarimaki, Laura Aliisa; Grafström, Roland; Kohonen, Pekka; Nymark, Penny; Willighagen, Egon; Puzyn, Tomasz; Rybinska-Fryca, Anna; Lyubartsev, Alexander; Jensen, Keld Alstrup; Brandenburg, Gerit; Lofts, Stephen; Svendsen, Claus; Harrison, Samuel; Maier, Dieter; Tamm, Kaido; Jänes, Jaak; Janes, Jaak; Sikk, Lauri; Dusinska, Maria; Longhin, Eleonora; Runden, Elise; Mariussen, Espen; El Yamani, Naouale; Unger, Wolfgang; Radnik, Jörg; Tropsha, Alexander; Cohen, Yoram; Leszcynski, Jerzy; Hendren, Christine Ogilvie; Wiesner, Mark; Winkler, David; Suzuki, Noriyuki; Yoon, Tae Hyun; Choi, Jang-Sik; Sanabria, Natasha; Gulumian, Mary; Lynch, Iseult
2020

Journal publication

Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Runden, Elise
2020

Conference lecture and academic presentation

HepG2 liver spheroids: promising advanced in vitro model for toxicity testing

Elje, Elisabeth; Dusinska, Maria; Mariussen, Espen; Hesler, Michelle; Kohl, Yvonne; Wagner, Sylvia; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Runden, Elise
2019

Journal publication

Mutational Imprints of Cobalt Exposure: A Genome-Scale Multi-system Approach.

Zavadil, J.; Melki, P. N.; Renard, C.; Mariussen, Espen; Runden, Elise; Longhin, Eleonora; Dusinska, Maria; Sancey, L.; Busser, B.; Herbert, R. A.; Korenjak, M.
2019

Report/thesis

NanoReg2 - case study. Test of genotoxicity and cytotoxicity of silica nanomaterials prepared by HiQ-Nano.

Mariussen, Espen; Hudecova, Alexandra Misci; Longhin, Eleonora; Dusinska, Maria; Runden, Elise
2019

Report/thesis

NanoReg2 - case study. Cytotoxicity and genotoxicity testing of carbon nanofibers prepared by Grupo Antolin.

Mariussen, Espen; Hudecova, Alexandra Misci; Dusinska, Maria; Runden, Elise
2019

Report/thesis

NanoReg2 - case study. Cytotoxicity- and genotoxicity-testing of silica nanomaterials prepared by Nanomakers.

Hudecova, Alexandra Misci; Mariussen, Espen; Dusinska, Maria; Runden, Elise
2019

Journal publication

The comet assay applied to HepG2 liver spheroids

Elje, Elisabeth; Hesler, Michelle; Runden, Elise; Mann, Pascal; Mariussen, Espen; Wagner, Sylvia; Dusinska, Maria; Kohl, Yvonne
2019

Part of a book/report

In vitro approaches for assessing the genotoxicity of nanomaterials

Dusinska, Maria; Mariussen, Espen; Runden, Elise; Hudecova, Alexandra Misci; Elje, Elisabeth; Kazimirova, Alena; El Yamani, Naouale; Dommershausen, Nils; Tharmann, Julian; Fieblinger, Dagmar; Herzberg, Frank; Luch, Andreas; Haase, Andrea
2019

Conference lecture and academic presentation

Correlation between the thermodynamic parameters of the nanoparticles/proteins interactions and the dominant contributions determining the toxicity of the nanomaterials

Tanasescu, Speranta; Precupas, Aura; Gheorghe, Daniela; Botea-Petcu, Alina; Sandu, Romica; Popa, Vlad T.; Runden, Elise; Mariussen, Espen; El Yamani, Naouale; Hudecova, Alexandra Misci; Dusinska, Maria; Giusti, Anna; Haase, Andrea
2018

Conference lecture and academic presentation

Grouping approaches for nanomaterials based on oxidative stress responses

Giusti, Anna; Tsekovska, Rositsa; Ionita, Gabriela; Pietraforte, Donatella; Baron, Flavia; Mariussen, Espen; Runden, Elise; Dusinska, Maria; Jacobsen, Nicklas Raun; Bahl, Aileen; Tanasescu, Speranta; Puzyn, Tomasz; Apostolova, Margarita; Haase, Andrea
2018

Conference lecture and academic presentation

3D models and organs on chip

Mariussen, Espen; Elje, Elisabeth; Hesler, Michelle; knoll, Thorsten; Runden, Elise; Dusinska, Maria; Kohl, Yvonne
2018

Conference lecture and academic presentation

Human liver spheroids as an advanced in vitro model for toxicity testing

Elje, Elisabeth; Dusinska, Maria; Mariussen, Espen; Runden, Elise
2018

Report/thesis

iNANOD liposomes. Cyto- and genotoxicity testing.

Runden, Elise; Hudecova, Alexandra Misci; Mariussen, Espen; Dusinska, Maria
2018

Conference lecture and academic presentation

Genotoxicity of nanomaterials in advanced in vitro model systems

Dusinska, Maria; Elje, Elisabeth; Mariussen, Espen; Gutleb, A.; Serchi, T.; Runden, Elise
2018

Conference lecture and academic presentation

Human in vitro liver 3D spheroid model in nanotoxicology.

Elje, Elisabeth; Dusinska, Maria; Mariussen, Espen; Runden, Elise
2018

Journal publication

The comet assay applied to cells of the eye

Azqueta, Amaya; Runden, Elise; Elje, Elisabeth; Nicolaissen, Bjørn; Haug, Kristiane; Smeringaiova, Ingrida; Jirsova, Katerina; Collins, Andrew Richard
2018

Journal publication

Genotoxicity of engineered nanoparticles

Dusinska, Maria; El Yamani, Naouale; Elje, Elisabeth; Runden, Elise
2018

Part of a book/report

Health hazard and risk assessment of nanoparticles applied in biomedicine

Drlickova, Martina; Smolkova, Bozena; Runden, Elise; Dusinska, Maria
2018

Report/thesis

Artificial turf. Preliminary study on potential genotoxicity of nanoparticles generated from football pitches.

Rundén-Pran, E., Dusinska, M., El Yamani, N., Dauge, F., Knudsen, S.
2017

Conference lecture and academic presentation

Cytotoxicity and genotoxicity of four reference metal nanomaterials: Towards reliable hazard assessment.

El Yamani, N., Collins, A. R., Rundén-Pran, E., Shaposhnikov, S., Dusinska, M.
2017

Conference lecture and academic presentation

Small, smart and safe (3S) nanoparticles: How to address their risk assessment with in vitro (3R) approaches.

Dusinska, M., Gabelova, A., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Conference lecture and academic presentation

Genotoxicity of engineered nanoparticles.

Dusinska, M., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Conference lecture and academic presentation

Safety assessment of nanoparticles with in vitro approaches.

Dusinska, M., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Journal publication

Genotoxicity of engineered nanoparticles.

Dusinska, M., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Journal publication

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Dusinska, M., Tulinska, J., El Yamani, N., Kuricova, M., Liskova, A., Rollerova, E., Rundén-Pran, E., Smolkova, B.
2017

Report/thesis

NILU's Strategic Institute Initiatives (SIS) 2016.

Aas, W., Rundén-Pran, E., Breivik, K., Sundseth, K., Høiskar, B. A., Platt, S., Castell, N., Schlabach, M.
2017

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays for testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Dusinska, M.
2017

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays for testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Dusinska, M.
2017

Part of a book/report

Application of the comet assay in nanotoxicology.

Dusinska, M., Rundén-Pran, E., El Yamani, N., Fjellsbø, L. M., Collins, A.
2017

Journal publication

In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment.

El Yamani, N., Collins, A.R., Rundén-Pran, E., Fjellsbo, L.M., Shaposhnikov, S., Zielonddiny, S., Dusinska, M.
2017

Journal publication

Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles.

Gabelova, A., El Yamani, N., Alonso, T.I., Buliakova, B., Srancikova, A., Babelova, A., Rundén-Pran, E., Fjellsbø, L.M., Elje, E., Yazdani, M., Silva, M.J., Dusinska, M.
2017

Journal publication

High throughput toxicity screening and intracellular detection of nanomaterials.

Collins, A. R., Annangi, B., Rubio, L., Marcos, R., Dorn, M., Merker, C., Estrela-Lopis, I., Cimpan, M. R., Ibrahim, M., Cimpan, E., Ostermann, M., Sauter, A., El Yamani, N., Shaposhnikov, S., Chevillard, S., Paget, V., Grall, R., Delic, J., de-Cerio, F. G.-., Suarez-Merino, B., Fessard, V., Hogeveen, K. N., Fjellsbø, L. M., Rundén-Pran, E., Brzicova, T., Topinka, J., Silva, M. J., Leite, P. E., Ribeiro, A. R., Granjeiro, J. M., Grafström, R., Prina-Mello, A., Dusinska, M.
2017

Conference lecture and academic presentation

HISENTS - High level Integrated SEnsor for NanoToxicity Screening, Health Effects Laboratory.

Rundén-Pran, E.
2016

Conference lecture and academic presentation

Hvordan påvirker miljøgifter helsa vår? Helseeffektlaboratoriet ved NILU.

Rundén-Pran, E.
2016

Conference lecture and academic presentation

ToxRos - Chemical and toxicological characterization of reactive atmospheric species.

Rundén-Pran, E.
2016

Conference lecture and academic presentation

High throughput comet assay: applications in genotoxicity testing of nanomaterials.

El Yamani, N., Collins, A. R., Rundén-Pran, E., Fjellsbø, L., Shaposhnikov, S., Dusinska, M.
2016

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays in relation to genotoxicity testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Fjellsbø, L. M., Dusinska. M.
2016

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays in relation to genotoxicity testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Fjellsbø, L. M., Dusinska, M.
2016

Conference lecture and academic presentation

Integrated testing for safety of nanoparticles.

Dusinska, M., El Yamani, N., Fjellsbø, L.M., Rundén-Pran E.
2016

Conference lecture and academic presentation

Mutagenic and carcinogenic potential of metal nanoparticles depends on physicochemical properties.

Dusinska, M., El Yamani, N., Fjellsbø, L. M., Huk, A., Gabelova, A., Rundén-Pran, E.
2016

Conference lecture and academic presentation

Advances in our understanding of nanomaterial carcinogenicity.

Dusinska, M., Gabelova, A., El Yamani, N., Fjellsbø, L. M., Silva, M.J., Rundén-Pran, E.
2016

Conference lecture and academic presentation

Nanoparticles: a hidden hazard?

Dusinska, M., El Yamani, N., Gabelova, A., Alonso T. I., Rundén-Pran, E., Fjellsbø, L. M., Silva, M. J., Shaposhnikov, S., Collins, A. R.
2016

Conference lecture and academic presentation

High throughput genotoxicity testing of nanomaterials.

Collins, A., El Yamani, N., Shaposhnikov, S., Rundén-Pran, E., Dusinska, M.
2016

Report/thesis

NILU's Strategic Institute Initiatives (SIS) 2015.

Aas, W., Breivik, K., Fiebig, M., Høiskar, B.A.K., Rundén-Pran, E., Schlabach, M., Sundseth, K.
2016

Conference lecture and academic presentation

High throughput comet assay to study genotoxicity of nanomaterials.

El Yamani, N., Rundén-Pran, E., Fjellsbø, L., Collins, A.R., Dusinska, M.
2015

Conference lecture and academic presentation

Hvordan påvirker luftforurensning helsa vår?

Rundén-Pran, E.
2015

Report/thesis

NILU's Strategic Institute Initiatives (SIS) 2014.

Lopez-Aparicio, S., Myhre, C.L., Fiebig, M., Schlabach, M., Aas, W., Breivik, K., Rundén-Pran, E.
2015

Journal publication

Towards an alternative testing strategy for nanomaterials used in nanomedicine: Lessons from NanoTEST.

Dusinska, M., Boland, S., Saunders, M., Juillerat-Jeanneret, L., Tran, L., Pojana, G., Marcomini, A., Volkovova, K., Tulinska, J., Knudsen, L.E., Gombau, L., Whelan, M., Collins, A.R., Marano, F,, Housiadas, C., Bilanicova, D., Kenzaoui, B.H., Carreira, S.C., Magdolenova, Z., Fjellsbø, L., Huk, A., Handy, R., Walker, L., Barancokova, M., Bartonova, A., Burello, E., Castell, J., Cowie, H., Drlickova, M., Guadagnini, R., Harris, H., Harju, M., Heimstad, E.S., Hurbankova, M., Kazimirova, A., Kovacikova, Z., Kuricova, M., Liskova, A., Milcamps, A., Neubauerova, E., Palosaari, T., Papazafiri, P., Pilou, M., Poulsen, M.S., Ross, B., Rundén-Pran, E., Sebekova, K., Staruchova, M., Vallotto, D., Worth, A.
2015

Journal publication

Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles.

Magdolenova, Z., Drlickova, M., Henjum, K., Rundén-Pran, E., Tulinska, J., Bilanicova, D., Pojana, G., Kazimirova, A., Barancokova, M., Kuricova, M., Liskova, A., Staruchova, M., Ciampor, F., Vavra, I., Lorenzo, Y., Collins, A., Rinna, A., Fjellsbø, L., Volkovova, K., Marcomini, A., Amiry-Moghaddam, M., Dusinska, M.
2015

Journal publication

Biological impact assessment of nanomaterial used in nanomedicine. Introduction to the NanoTEST project.

Juillerat, L., Fjellsbø, L.M., Dusinska, M., Collins, A.R., Handy, R., Riediker, M., the NanoTEST Consortium
2015

Conference lecture and academic presentation

Genotoxicity of nanomaterials. Do we have testing strategy?

Dusinska, M., Huk, A., El Yamani, N., Fjellsbø, L.M., Rinna, A., Rundén-Pran, E., NanoTEST team.
2014

Journal publication

Human health risk assessment of nitrosamines and nitramines for potential application in CO2 capture.

Ravnum, S., Rundén-Pran, E., Fjellsbø, L.M., Dusinska, M.
2014

Journal publication

Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea.

Hudecova, A., Kusznierewicz, B., Rundén-Pran, E., Magdolenova, Z., Hasplova, K., Rinna, A., Fjellsbø, L.M., Kruszewski, M., Lankoff, A., Sandberg, W.J., Refsnes, M., Skuland, T., Schwarze, P., Brunborg, G., Bjøras, M., Collins, A., Miadoková, E., Galova, E., Dusinska, M.
2012

Part of a book/report

Critical evaluation of toxicity tests.

Dusinska, M., Rundén-Pran, E., Carreira, S.C., Saunders, M.
2012

Report/thesis

Alternative approaches to standard toxicity testing. TQP ID 9-OPTION-257430181-NILU.

Harju, M., Ravnum, S., Rundén-Pran, E., Grossberndt, S., Fjellsbø, L.M., Dusinska, M., Heimstad, E.S.
2011

Part of a book/report

Toxicity of silver nanomaterials in higher eukaryotes.

Kruszewski, M., Brzoska, K., Brunborg, G., Asare, N., Dobrzynska, M., Dusinska, M., Fjellsbø, L.M., Georgantzopoulou, A., Gromadzka-Ostrowska, J., Gutleb, A.C., Lankoff, A., Magdolenova, Z., Rundén-Pran, E., Rinna, A., Instanes, C., Sandberg, W.J., Schwarze, P., Stepkowski, T., Wojewódzka, M., Refsnes, M.
2011

Journal publication

Validation of organotypical hippocampal slice cultures as an ex vivo model of brain ischemia: different roles of NMDA receptors in cell death signalling after exposure to NMDA or oxygen and glucose deprivation.

Ahlgren, H., Henjum, K., Ottersen, O.P., Rundén-Pran, E.
2011

Part of a book/report

Safety of nanoparticles in medicine.

Dusinska, M., Fjellsbø, L.M., Magdolenova, Z., Ravnum, S., Rinna, A., Rundén-Pran, E.
2011

Journal publication

Impact of nanomaterials on human health: lessons from in vitro and animal models.

Kruszewski, M., Dusinska, M., Dobrzynska, M., Gromadzka-Ostrowska, J., Brunborg, G., Lankoff, A., Wojewodzka, M., Sommer, S., Brzoska, K., Meczynska-Wielgosz , S., Rumianek , K., Wojciuk, G., Stepkowski, T., Gradzka, I., Buraczewska, T., Schwarze, P.E., Refsnes, M., Sandberg, W., Asare, N., Instanes, C., Dziendzikowska, K., Oczkowski, M., Krawczynska, A., Gajowik, A., Radzikowska, J., Fjellsbø, L.M., Magdolenova, Z., Rinna, A., Rundén-Pran, E., Hudecova, A., Hasplova, K.
2010

Part of a book/report

Nanogenotoxicology. Application of the comet assay in genotoxicity testing of nanomaterials.

Dusinska, M., Magdolenova, Z., Fjellsbø, L.M., Hudecova, A., Hasplova, K., Rinna, A., Rundén-Pran, E.
2009

Journal publication

The safety of nanoparticles used in medical application. Development of alternative testing strategies for toxicity testing.

Dusinska, M., NanoTEST consortium
2009

Journal publication

Testing strategies for the safety of nanoparticles used in medical applications.

Dusinska, M., NanoTEST consortium
2009

Conference lecture and academic presentation

Application of organotypical slice cultures for investigating selective neurotoxicity of nanoparticles.

Rundén-Pran, E., Dusinska, M., Ottersen, O.P.
2009

Conference lecture and academic presentation

Impact of nanomaterials on human health: lessons from in vitro and animal models.

Magdolenova, Z., Dusinska, M., Fjellsbø, L.M., Schwarze, P., Brunborg, G., Wojewódzka, M., Dobrzynska, M., Gromadzka, J., Lankoff, A., Instanes, C., Refsnes, M., Låg, M., Rundén-Pran, E., Kruszewski, M.
2009

Glutamate Oxaloacetate Transaminase Nanoparticles targeted to the Brain for Neuroprotection in Ischemic Stroke (GOTTARG)

The project will develop and test the first targeted and long-acting nanomedicine with neuroprotective properties for ischemic stroke, with potential application in other neurological diseases. The Team will demonstrate that […]

Project period: 2020 – 2022

Ongoing

Innovative Nanopharmaceuticals: Targeting Breast Cancer Stem Cells by Novel Combination of Epigenetic and Anticancer Drugs with Gene Therapy (INNOCENT)

A challenge in the treatment of breast cancer patients is frequent relapses. This project focuses at circulating cancer stem cells, which are a main cause of relapses in the patients. The aim of this project is to develop a new drug for treatment of breast cancer, by targeting stem cells, based on nanoparticles.

Project period: 2017 – 2020

Concluded

The treatment is based on combining chemotherapy with epigenetics, gene- and radiotherapy into a new nanopharmaceutical – COMBOBOMB. The whole project is in accordance with the safe-by-design principle, where toxicity testing is being performed in parallel with the development of the drug to ensure development of a drug with high efficacy and no serious side effects.

The partners in this project are from Slovakia (coordinator), Greece, Spain, Latvia and Norway (http://www.innocent.pixellaris.com/index.html). Toxicity testing is being performed by the Norwegian partners in close collaboration with the partners developing the nanomaterials. The project partners have selected four cell lines relevant to breast cancer to be applied for toxicity testing, and cell banks have been established. Standard operating procedures (SOPs) have been developed for cultivation of the cells lines and to investigate induction of cell death or DNA damage (cyto- or genotoxicity) by the nanomaterials. A common challenge within nanotoxicology, is interference between the test method and the nanomaterial to be tested. Thus, it is important to apply test methods validated for toxicity testing of nanomaterials.

For testing of cell death (cytotoxicity), several SOPs for different test methods (both colorimetric and label-free) have been worked out: impedance measurements, tryphan blue assay, alamar blue assay (AB) and colony forming efficiency (CFE). One of the drawbacks of traditional laboratory toxicity tests is that they are done under static conditions and do not reflect the dynamics of real life processes. Therefore, UiB have developed an innovative microfluidic device that will mimic better the exposure of breast cancer cells in the body. An advanced 3D in vitro model for breast cancer cells, better reflecting the in vivo situation, is being developed by NILU, and UiB has fabricated a multi-compartment microfluidic chip to support the growth of breast cancer cells, tumor associated stromal cells and microvasculature.

For genotoxicity testing, the modified version of the comet assay is applied to detect DNA strand breaks and specific oxidized DNA base lesions. NILU has modified and validated the comet assay, as well as AB and CFE, for higher throughput measurements and applicability for nanomaterials. Additionally, NILU has established gene mutation tests (Mouse lymphoma assay and HPRT) and test for cancer induction (cell transformation assay; in vitro test for carcinogenicity), and the latter assay has also be modified for higher throughput. UiB and NILU have established the test systems and have tested the received reference gold (Au) nanomaterials on the relevant cellular models for validation of the test models for testing of nanoparticles.

Toxicity of nanomaterials is strongly dependent upon physio-chemical properties, as size. Thus, it is important to analyze size and size distribution of the nanomaterials in the actual dispersion to be applied. SOPs have been established for physiochemical characterization of size and size distribution of nanoparticles in stock as well as in cell culture media by use of nanoparticle tracking analysis (NTA) and dynamic light scattering (DLS). Stability of liposome formulations in different dispersion media were analyzed by DLS.

There have been some challenges with designing nanoparticles that are selectively taken up by breast cancer cells and not by normal breast cell. UiB has performed uptake analysis of different liposome (nanocarrier) formulations and with different surface coatings, to detect the most promising candidate for selective uptake in cancer cells and thus targeted delivery. A candidate nanoparticle was selected for further processing, and surface coating modified to obtain increased selective delivery to breast cancer stem cells. Cytotoxicity of the nanocarriers were tested and found not to be cytotoxic by monitoring in real-time via cell-substrate electrical impedance sensing. Work with design and testing of nanocarriers for selective uptake is ongoing.

Elise Rundén-Pran has 79 publications at NILU

Conference lecture and academic presentation

Financial management

Longhin, Eleonora; Runden, Elise
2021

Conference lecture and academic presentation

Nanosafety: challenges and opportunities

Runden, Elise
2021

Journal publication

An Advanced In vitro Respiratory Model for Genotoxicity Testing at the Air-Liquid Interface

Runden, Elise; Mariussen, Espen; Elje, Elisabeth; Chary, A.; Longhin, Eleonora; El Yamani, Naouale; Dusinska, Maria; Gutleb, A.; Serchi, T.
2021

Journal publication

In silico unravelling of descriptors for cytotoxicity and genotoxicity for hazard identification of nanomaterials

El Yamani, Naouale; Gromelski, Maciej; Mariussen, Espen; Wyrzykowska, E.; Grabarek, D.; Puzyn, Tomasz; Dusinska, Maria; Runden, Elise
2021

Journal publication

Micronucleus assay applied to advanced in vitro lung models at ALI for nanotoxicity assessment

Elje, Elisabeth; Mariussen, Espen; Dusinska, Maria; Runden, Elise
2021

Journal publication

Standardisation of mutagenicity testing approaches, tailored to the evaluation of engineered nanomaterials

Burgum, Michael J.; El Yamani, Naouale; Sosnowska, Anita; Stolinski, Filip; Longhin, Eleonora; Mariussen, Espen; Runden, Elise; Jenkins, Gareth; Clift, Martin J. D.; Puzyn, Tomasz; Dusinska, Maria; Doak, Shareen H.
2021

Journal publication

Towards FAIR nanosafety data

Jeliazkova, Nina; Apostolova, Margarita; Andreoli, Cristina; Barone, Flavia; Barrick, Andrew; Battistelli, Chiara L.; Bossa, Cecilia; Botea-Petcu, Alina; Chatel, Amelie; De Angelis, Isabella; Dusinska, Maria; El Yamani, Naouale; Gheorghe, Daniela; Giusti, Anna; Gómez-Fernández, Paloma; Grafström, Roland; Gromelski, Maciej; Jacobsen, Nicklas Raun; Jeliazkov, Vedrin; Jensen, Keld Alstrup; Kochev, Nikolay; Kohonen, Pekka; Manier, Nicolas; Mariussen, Espen; Mech, Agnieszka; Navas, José María; Paskaleva, Vesselina; Precupas, Aurica; Puzyn, Tomasz; Rasmussen, Kirsten; Ritchie, Peter; Llopis, Isabel Rodriguez; Runden, Elise; Sandu, Romica; Shandilya, Neeraj; Tanasescu, Sperenta; Haase, Andrea; Nymark, Penny
2021

Journal publication

Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening

Kohl, Yvonne; Biehl, Margit; Spring, Sarah; Hesler, Michelle; Ogourtsov, Vladimir; Todorovic, Miomir; Owen, Joshua; Elje, Elisabeth; Kopecka, Kristina; Moriones, Oscar H.; Bastus, Neus G.; Simon, Peter; Dubaj, Tibor; Runden, Elise; Puntes, Victor; William, Nicola; von Briesen, Hagen; Wagner, Sylvia; Kapur, Nikil; Mariussen, Espen; Nelson, Andrew; Gabelova, A; Dusinska, Maria; Velten, Thomas; knoll, Thorsten
2021

Journal publication

A scoping review of systematic reviews on environmental effects of sunscreen ingredients. Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids, Materials in Contact with Food, and Cosmetics of the Norwegian Scientific Committee for Food and Environment

Svendsen, Camilla; Asmyhr, Maria Gulbrandsen; Denison, Eva Marie-Louise; Devold, Tove Gulbrandsen; Mathisen, Gro Haarklou; Rohloff, Jens; Starrfelt, Jostein; Bruzell, Ellen; Carlsen, Monica Hauger; Granum, Berit; Runden, Elise; Rasinger, Josef Daniel; Husøy, Trine
2020

Conference lecture and academic presentation

Development of an Adverse Outcome Pathway for Chronic and Multi-Generational Impacts of Nanomaterials in the Environmental Indicator Species Daphnia Magna

Lynch, Iseult; Reilly, Katie; Cimpan, Mihaela Roxana; Drønen, Anne-Marthe; Rios-Mondragon, Ivan; Cambier, Sébastien; Gutleb, Arno; Serchi, Tommaso; Dusinska, Maria; Runden, Elise; Mariussen, Espen; Longhin, Eleonora; Murugadoss, Sivakumar; Hoet, Peter; Willihagen, Egon; Martens, Marvin; Afantitis, Antreas; Melargakis, Georgia; Vincovik Vrcek, Ivana
2020

Journal publication

Safe(r) by design implementation in the nanotechnology industry

Jiménes, Araceli Sánchez; Puelles, Raquel; Pérez-Fernández, Marta; Gómez-Fernández, Paloma; Barruetabena, Leire; Jacobsen, Nicklas Raun; Suarez-Merino, Blanca; Micheletti, Christian; Manier, Nicolas; Trouiller, Benedicte; Navas, José Maria; Kalman, Judit; Salieri, Beatrice; Hischier, Roland; Handzhiyski, Yordan; Apostolova, Margarita; Hadrup, Niels; Bouillard, Jaques; Oudart, Yohan; Merino, Cesar; Garcia, Erika; Liguori, Biase; Sabella, Stefania; Rose, Jerome; Maison, Armand; Galea, Karen S.; Kelly, Sean; Stepankova, Sandra; Mouneyrac, Catherine; Barrick, Andrew; Chatel, Amelie; Dusinska, Maria; Runden, Elise; Mariussen, Espen; Bressot, Christophe; Aguerre-Chariol, Olivier; Shandilya, Neeraj; Goede, Henk; Gomez-Cordon, Julio; Simar, Sophie; Nesslany, Fabrice; Jensen, Keld Alstrup; Van Tongeren, Martie; Llopis, Isabel Rodriguez
2020

Journal publication

Genotoxicity of nanomaterials: Advanced in vitro models and high throughput methods for human hazard assessment—a review

Kohl, Yvonne; Runden, Elise; Mariussen, Espen; Hesler, Michelle; El Yamani, Naouale; Longhin, Eleonora; Dusinska, Maria
2020

Journal publication

Risk governance of emerging technologies demonstrated in terms of its applicability to nanomaterials

Isigonis, Panagiotis; Afantitis, Antreas; Antunes, Dalila; Bartonova, Alena; Beitollahi, Ali; Bohmer, Nils; Bouman, Evert; Chaudhry, Qasim; Cimpan, Mihaela Roxana; Cimpan, Emil; Doak, Shareen H.; Dupin, Damien; Fredrigo, Doreen; Fessard, Valérie; Gromelski, Maciej; Gutleb, Arno C.; Halappanavar, Sabina; Hoet, Peter; Jeliazkova, Nina; Jomini, Stephane; Lindner, Sabine; Linkov, Igor; Longhin, Eleonora; Lynch, Iseult; Malsch, Ineke; Marcomini, Antonio; Mariussen, Espen; de la Fuente, Jesus M.; Melagraki, Georgia; Murphy, Finbarr; Neaves, Michael; Packroff, Rolf; Pfuhler, Stefan; Puzyn, Tomasz; Rahman, Qamar; Runden, Elise; Semenzin, Elena; Serchi, Tommaso; Steinbach, Christoph; Trump, Benjamin; Vrcek, Ivana Vinkovic; Warheit, David; Wiesner, Mark; Willighagen, Egon; Dusinska, Maria
2020

Journal publication

Thermodynamic parameters at bio-nano interface and nanomaterial toxicity: A case study on BSA interaction with ZnO, SiO2 and TiO2

Precupas, Aurica; Gheorghe, Daniela; Botea-Petcu, Alina; Leonties, Anca Ruxandra; Sandu, Romica; Popa, Vlad T.; Mariussen, Espen; El Yamani, Naouale; Runden, Elise; Dumit, Veronica; Xue, Ying; Cimpan, Mihaela Roxana; Dusinska, Maria; Haase, Andrea; Tanasescu, Speranta
2020

Journal publication

NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment

Afantitis, Antreas; Melagraki, Georgia; Isigonis, Panagiotis; Tsoumanis, Andreas; Varsou, Dimitra Danai; Valsami-Jones, Eugenia; Papadiamantis, Anastasios; Ellis, Laura-Jayne; Sarimveis, Haralambos; Doganis, Philip; Karatzas, Pantelis; Tsiros, Periklis; Liampa, Irene; Lobaskin, Vladimir; Greco, Dario; Serra, Angela; Kinaret, Pia Anneli Sofia; Saarimaki, Laura Aliisa; Grafström, Roland; Kohonen, Pekka; Nymark, Penny; Willighagen, Egon; Puzyn, Tomasz; Rybinska-Fryca, Anna; Lyubartsev, Alexander; Jensen, Keld Alstrup; Brandenburg, Gerit; Lofts, Stephen; Svendsen, Claus; Harrison, Samuel; Maier, Dieter; Tamm, Kaido; Jänes, Jaak; Janes, Jaak; Sikk, Lauri; Dusinska, Maria; Longhin, Eleonora; Runden, Elise; Mariussen, Espen; El Yamani, Naouale; Unger, Wolfgang; Radnik, Jörg; Tropsha, Alexander; Cohen, Yoram; Leszcynski, Jerzy; Hendren, Christine Ogilvie; Wiesner, Mark; Winkler, David; Suzuki, Noriyuki; Yoon, Tae Hyun; Choi, Jang-Sik; Sanabria, Natasha; Gulumian, Mary; Lynch, Iseult
2020

Journal publication

Hepato(Geno)Toxicity Assessment of Nanoparticles in a HepG2 Liver Spheroid Model

Elje, Elisabeth; Mariussen, Espen; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Kohl, Yvonne; Dusinska, Maria; Runden, Elise
2020

Conference lecture and academic presentation

HepG2 liver spheroids: promising advanced in vitro model for toxicity testing

Elje, Elisabeth; Dusinska, Maria; Mariussen, Espen; Hesler, Michelle; Kohl, Yvonne; Wagner, Sylvia; Moriones, Oscar H.; Bastus, Neus G.; Puntes, Victor; Runden, Elise
2019

Journal publication

Mutational Imprints of Cobalt Exposure: A Genome-Scale Multi-system Approach.

Zavadil, J.; Melki, P. N.; Renard, C.; Mariussen, Espen; Runden, Elise; Longhin, Eleonora; Dusinska, Maria; Sancey, L.; Busser, B.; Herbert, R. A.; Korenjak, M.
2019

Report/thesis

NanoReg2 - case study. Test of genotoxicity and cytotoxicity of silica nanomaterials prepared by HiQ-Nano.

Mariussen, Espen; Hudecova, Alexandra Misci; Longhin, Eleonora; Dusinska, Maria; Runden, Elise
2019

Report/thesis

NanoReg2 - case study. Cytotoxicity and genotoxicity testing of carbon nanofibers prepared by Grupo Antolin.

Mariussen, Espen; Hudecova, Alexandra Misci; Dusinska, Maria; Runden, Elise
2019

Report/thesis

NanoReg2 - case study. Cytotoxicity- and genotoxicity-testing of silica nanomaterials prepared by Nanomakers.

Hudecova, Alexandra Misci; Mariussen, Espen; Dusinska, Maria; Runden, Elise
2019

Journal publication

The comet assay applied to HepG2 liver spheroids

Elje, Elisabeth; Hesler, Michelle; Runden, Elise; Mann, Pascal; Mariussen, Espen; Wagner, Sylvia; Dusinska, Maria; Kohl, Yvonne
2019

Part of a book/report

In vitro approaches for assessing the genotoxicity of nanomaterials

Dusinska, Maria; Mariussen, Espen; Runden, Elise; Hudecova, Alexandra Misci; Elje, Elisabeth; Kazimirova, Alena; El Yamani, Naouale; Dommershausen, Nils; Tharmann, Julian; Fieblinger, Dagmar; Herzberg, Frank; Luch, Andreas; Haase, Andrea
2019

Conference lecture and academic presentation

Correlation between the thermodynamic parameters of the nanoparticles/proteins interactions and the dominant contributions determining the toxicity of the nanomaterials

Tanasescu, Speranta; Precupas, Aura; Gheorghe, Daniela; Botea-Petcu, Alina; Sandu, Romica; Popa, Vlad T.; Runden, Elise; Mariussen, Espen; El Yamani, Naouale; Hudecova, Alexandra Misci; Dusinska, Maria; Giusti, Anna; Haase, Andrea
2018

Conference lecture and academic presentation

Grouping approaches for nanomaterials based on oxidative stress responses

Giusti, Anna; Tsekovska, Rositsa; Ionita, Gabriela; Pietraforte, Donatella; Baron, Flavia; Mariussen, Espen; Runden, Elise; Dusinska, Maria; Jacobsen, Nicklas Raun; Bahl, Aileen; Tanasescu, Speranta; Puzyn, Tomasz; Apostolova, Margarita; Haase, Andrea
2018

Conference lecture and academic presentation

3D models and organs on chip

Mariussen, Espen; Elje, Elisabeth; Hesler, Michelle; knoll, Thorsten; Runden, Elise; Dusinska, Maria; Kohl, Yvonne
2018

Conference lecture and academic presentation

Human liver spheroids as an advanced in vitro model for toxicity testing

Elje, Elisabeth; Dusinska, Maria; Mariussen, Espen; Runden, Elise
2018

Report/thesis

iNANOD liposomes. Cyto- and genotoxicity testing.

Runden, Elise; Hudecova, Alexandra Misci; Mariussen, Espen; Dusinska, Maria
2018

Conference lecture and academic presentation

Genotoxicity of nanomaterials in advanced in vitro model systems

Dusinska, Maria; Elje, Elisabeth; Mariussen, Espen; Gutleb, A.; Serchi, T.; Runden, Elise
2018

Conference lecture and academic presentation

Human in vitro liver 3D spheroid model in nanotoxicology.

Elje, Elisabeth; Dusinska, Maria; Mariussen, Espen; Runden, Elise
2018

Journal publication

The comet assay applied to cells of the eye

Azqueta, Amaya; Runden, Elise; Elje, Elisabeth; Nicolaissen, Bjørn; Haug, Kristiane; Smeringaiova, Ingrida; Jirsova, Katerina; Collins, Andrew Richard
2018

Journal publication

Genotoxicity of engineered nanoparticles

Dusinska, Maria; El Yamani, Naouale; Elje, Elisabeth; Runden, Elise
2018

Part of a book/report

Health hazard and risk assessment of nanoparticles applied in biomedicine

Drlickova, Martina; Smolkova, Bozena; Runden, Elise; Dusinska, Maria
2018

Report/thesis

Artificial turf. Preliminary study on potential genotoxicity of nanoparticles generated from football pitches.

Rundén-Pran, E., Dusinska, M., El Yamani, N., Dauge, F., Knudsen, S.
2017

Conference lecture and academic presentation

Cytotoxicity and genotoxicity of four reference metal nanomaterials: Towards reliable hazard assessment.

El Yamani, N., Collins, A. R., Rundén-Pran, E., Shaposhnikov, S., Dusinska, M.
2017

Conference lecture and academic presentation

Small, smart and safe (3S) nanoparticles: How to address their risk assessment with in vitro (3R) approaches.

Dusinska, M., Gabelova, A., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Conference lecture and academic presentation

Genotoxicity of engineered nanoparticles.

Dusinska, M., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Conference lecture and academic presentation

Safety assessment of nanoparticles with in vitro approaches.

Dusinska, M., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Journal publication

Genotoxicity of engineered nanoparticles.

Dusinska, M., El Yamani, N., Elje, E., Rundén-Pran, E.
2017

Journal publication

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Dusinska, M., Tulinska, J., El Yamani, N., Kuricova, M., Liskova, A., Rollerova, E., Rundén-Pran, E., Smolkova, B.
2017

Report/thesis

NILU's Strategic Institute Initiatives (SIS) 2016.

Aas, W., Rundén-Pran, E., Breivik, K., Sundseth, K., Høiskar, B. A., Platt, S., Castell, N., Schlabach, M.
2017

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays for testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Dusinska, M.
2017

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays for testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Dusinska, M.
2017

Part of a book/report

Application of the comet assay in nanotoxicology.

Dusinska, M., Rundén-Pran, E., El Yamani, N., Fjellsbø, L. M., Collins, A.
2017

Journal publication

In vitro genotoxicity testing of four reference metal nanomaterials, titanium dioxide, zinc oxide, cerium oxide and silver: towards reliable hazard assessment.

El Yamani, N., Collins, A.R., Rundén-Pran, E., Fjellsbo, L.M., Shaposhnikov, S., Zielonddiny, S., Dusinska, M.
2017

Journal publication

Fibrous shape underlies the mutagenic and carcinogenic potential of nanosilver while surface chemistry affects the biosafety of iron oxide nanoparticles.

Gabelova, A., El Yamani, N., Alonso, T.I., Buliakova, B., Srancikova, A., Babelova, A., Rundén-Pran, E., Fjellsbø, L.M., Elje, E., Yazdani, M., Silva, M.J., Dusinska, M.
2017

Journal publication

High throughput toxicity screening and intracellular detection of nanomaterials.

Collins, A. R., Annangi, B., Rubio, L., Marcos, R., Dorn, M., Merker, C., Estrela-Lopis, I., Cimpan, M. R., Ibrahim, M., Cimpan, E., Ostermann, M., Sauter, A., El Yamani, N., Shaposhnikov, S., Chevillard, S., Paget, V., Grall, R., Delic, J., de-Cerio, F. G.-., Suarez-Merino, B., Fessard, V., Hogeveen, K. N., Fjellsbø, L. M., Rundén-Pran, E., Brzicova, T., Topinka, J., Silva, M. J., Leite, P. E., Ribeiro, A. R., Granjeiro, J. M., Grafström, R., Prina-Mello, A., Dusinska, M.
2017

Conference lecture and academic presentation

HISENTS - High level Integrated SEnsor for NanoToxicity Screening, Health Effects Laboratory.

Rundén-Pran, E.
2016

Conference lecture and academic presentation

Hvordan påvirker miljøgifter helsa vår? Helseeffektlaboratoriet ved NILU.

Rundén-Pran, E.
2016

Conference lecture and academic presentation

ToxRos - Chemical and toxicological characterization of reactive atmospheric species.

Rundén-Pran, E.
2016

Conference lecture and academic presentation

High throughput comet assay: applications in genotoxicity testing of nanomaterials.

El Yamani, N., Collins, A. R., Rundén-Pran, E., Fjellsbø, L., Shaposhnikov, S., Dusinska, M.
2016

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays in relation to genotoxicity testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Fjellsbø, L. M., Dusinska. M.
2016

Conference lecture and academic presentation

Comparison of in vitro human cytotoxicity assays in relation to genotoxicity testing of nanomaterials.

Rundén-Pran, E., El Yamani, N., Fjellsbø, L. M., Dusinska, M.
2016

Conference lecture and academic presentation

Integrated testing for safety of nanoparticles.

Dusinska, M., El Yamani, N., Fjellsbø, L.M., Rundén-Pran E.
2016

Conference lecture and academic presentation

Mutagenic and carcinogenic potential of metal nanoparticles depends on physicochemical properties.

Dusinska, M., El Yamani, N., Fjellsbø, L. M., Huk, A., Gabelova, A., Rundén-Pran, E.
2016

Conference lecture and academic presentation

Advances in our understanding of nanomaterial carcinogenicity.

Dusinska, M., Gabelova, A., El Yamani, N., Fjellsbø, L. M., Silva, M.J., Rundén-Pran, E.
2016

Conference lecture and academic presentation

Nanoparticles: a hidden hazard?

Dusinska, M., El Yamani, N., Gabelova, A., Alonso T. I., Rundén-Pran, E., Fjellsbø, L. M., Silva, M. J., Shaposhnikov, S., Collins, A. R.
2016

Conference lecture and academic presentation

High throughput genotoxicity testing of nanomaterials.

Collins, A., El Yamani, N., Shaposhnikov, S., Rundén-Pran, E., Dusinska, M.
2016

Report/thesis

NILU's Strategic Institute Initiatives (SIS) 2015.

Aas, W., Breivik, K., Fiebig, M., Høiskar, B.A.K., Rundén-Pran, E., Schlabach, M., Sundseth, K.
2016

Conference lecture and academic presentation

High throughput comet assay to study genotoxicity of nanomaterials.

El Yamani, N., Rundén-Pran, E., Fjellsbø, L., Collins, A.R., Dusinska, M.
2015

Conference lecture and academic presentation

Hvordan påvirker luftforurensning helsa vår?

Rundén-Pran, E.
2015

Report/thesis

NILU's Strategic Institute Initiatives (SIS) 2014.

Lopez-Aparicio, S., Myhre, C.L., Fiebig, M., Schlabach, M., Aas, W., Breivik, K., Rundén-Pran, E.
2015

Journal publication

Towards an alternative testing strategy for nanomaterials used in nanomedicine: Lessons from NanoTEST.

Dusinska, M., Boland, S., Saunders, M., Juillerat-Jeanneret, L., Tran, L., Pojana, G., Marcomini, A., Volkovova, K., Tulinska, J., Knudsen, L.E., Gombau, L., Whelan, M., Collins, A.R., Marano, F,, Housiadas, C., Bilanicova, D., Kenzaoui, B.H., Carreira, S.C., Magdolenova, Z., Fjellsbø, L., Huk, A., Handy, R., Walker, L., Barancokova, M., Bartonova, A., Burello, E., Castell, J., Cowie, H., Drlickova, M., Guadagnini, R., Harris, H., Harju, M., Heimstad, E.S., Hurbankova, M., Kazimirova, A., Kovacikova, Z., Kuricova, M., Liskova, A., Milcamps, A., Neubauerova, E., Palosaari, T., Papazafiri, P., Pilou, M., Poulsen, M.S., Ross, B., Rundén-Pran, E., Sebekova, K., Staruchova, M., Vallotto, D., Worth, A.
2015

Journal publication

Coating-dependent induction of cytotoxicity and genotoxicity of iron oxide nanoparticles.

Magdolenova, Z., Drlickova, M., Henjum, K., Rundén-Pran, E., Tulinska, J., Bilanicova, D., Pojana, G., Kazimirova, A., Barancokova, M., Kuricova, M., Liskova, A., Staruchova, M., Ciampor, F., Vavra, I., Lorenzo, Y., Collins, A., Rinna, A., Fjellsbø, L., Volkovova, K., Marcomini, A., Amiry-Moghaddam, M., Dusinska, M.
2015

Journal publication

Biological impact assessment of nanomaterial used in nanomedicine. Introduction to the NanoTEST project.

Juillerat, L., Fjellsbø, L.M., Dusinska, M., Collins, A.R., Handy, R., Riediker, M., the NanoTEST Consortium
2015

Conference lecture and academic presentation

Genotoxicity of nanomaterials. Do we have testing strategy?

Dusinska, M., Huk, A., El Yamani, N., Fjellsbø, L.M., Rinna, A., Rundén-Pran, E., NanoTEST team.
2014

Journal publication

Human health risk assessment of nitrosamines and nitramines for potential application in CO2 capture.

Ravnum, S., Rundén-Pran, E., Fjellsbø, L.M., Dusinska, M.
2014

Journal publication

Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea.

Hudecova, A., Kusznierewicz, B., Rundén-Pran, E., Magdolenova, Z., Hasplova, K., Rinna, A., Fjellsbø, L.M., Kruszewski, M., Lankoff, A., Sandberg, W.J., Refsnes, M., Skuland, T., Schwarze, P., Brunborg, G., Bjøras, M., Collins, A., Miadoková, E., Galova, E., Dusinska, M.
2012

Part of a book/report

Critical evaluation of toxicity tests.

Dusinska, M., Rundén-Pran, E., Carreira, S.C., Saunders, M.
2012

Report/thesis

Alternative approaches to standard toxicity testing. TQP ID 9-OPTION-257430181-NILU.

Harju, M., Ravnum, S., Rundén-Pran, E., Grossberndt, S., Fjellsbø, L.M., Dusinska, M., Heimstad, E.S.
2011

Part of a book/report

Toxicity of silver nanomaterials in higher eukaryotes.

Kruszewski, M., Brzoska, K., Brunborg, G., Asare, N., Dobrzynska, M., Dusinska, M., Fjellsbø, L.M., Georgantzopoulou, A., Gromadzka-Ostrowska, J., Gutleb, A.C., Lankoff, A., Magdolenova, Z., Rundén-Pran, E., Rinna, A., Instanes, C., Sandberg, W.J., Schwarze, P., Stepkowski, T., Wojewódzka, M., Refsnes, M.
2011

Journal publication

Validation of organotypical hippocampal slice cultures as an ex vivo model of brain ischemia: different roles of NMDA receptors in cell death signalling after exposure to NMDA or oxygen and glucose deprivation.

Ahlgren, H., Henjum, K., Ottersen, O.P., Rundén-Pran, E.
2011

Part of a book/report

Safety of nanoparticles in medicine.

Dusinska, M., Fjellsbø, L.M., Magdolenova, Z., Ravnum, S., Rinna, A., Rundén-Pran, E.
2011

Journal publication

Impact of nanomaterials on human health: lessons from in vitro and animal models.

Kruszewski, M., Dusinska, M., Dobrzynska, M., Gromadzka-Ostrowska, J., Brunborg, G., Lankoff, A., Wojewodzka, M., Sommer, S., Brzoska, K., Meczynska-Wielgosz , S., Rumianek , K., Wojciuk, G., Stepkowski, T., Gradzka, I., Buraczewska, T., Schwarze, P.E., Refsnes, M., Sandberg, W., Asare, N., Instanes, C., Dziendzikowska, K., Oczkowski, M., Krawczynska, A., Gajowik, A., Radzikowska, J., Fjellsbø, L.M., Magdolenova, Z., Rinna, A., Rundén-Pran, E., Hudecova, A., Hasplova, K.
2010

Part of a book/report

Nanogenotoxicology. Application of the comet assay in genotoxicity testing of nanomaterials.

Dusinska, M., Magdolenova, Z., Fjellsbø, L.M., Hudecova, A., Hasplova, K., Rinna, A., Rundén-Pran, E.
2009

Journal publication

The safety of nanoparticles used in medical application. Development of alternative testing strategies for toxicity testing.

Dusinska, M., NanoTEST consortium
2009

Journal publication

Testing strategies for the safety of nanoparticles used in medical applications.

Dusinska, M., NanoTEST consortium
2009

Conference lecture and academic presentation

Application of organotypical slice cultures for investigating selective neurotoxicity of nanoparticles.

Rundén-Pran, E., Dusinska, M., Ottersen, O.P.
2009

Conference lecture and academic presentation

Impact of nanomaterials on human health: lessons from in vitro and animal models.

Magdolenova, Z., Dusinska, M., Fjellsbø, L.M., Schwarze, P., Brunborg, G., Wojewódzka, M., Dobrzynska, M., Gromadzka, J., Lankoff, A., Instanes, C., Refsnes, M., Låg, M., Rundén-Pran, E., Kruszewski, M.
2009

Glutamate Oxaloacetate Transaminase Nanoparticles targeted to the Brain for Neuroprotection in Ischemic Stroke (GOTTARG)

The project will develop and test the first targeted and long-acting nanomedicine with neuroprotective properties for ischemic stroke, with potential application in other neurological diseases. The Team will demonstrate that […]

Project period: 2020 – 2022

Ongoing

Innovative Nanopharmaceuticals: Targeting Breast Cancer Stem Cells by Novel Combination of Epigenetic and Anticancer Drugs with Gene Therapy (INNOCENT)

A challenge in the treatment of breast cancer patients is frequent relapses. This project focuses at circulating cancer stem cells, which are a main cause of relapses in the patients. The aim of this project is to develop a new drug for treatment of breast cancer, by targeting stem cells, based on nanoparticles.

Project period: 2017 – 2020

Concluded